Summary
The conversation revolves around a medical case scenario discussing a 53-year-old female patient with hypertension, diabetes, and rheumatoid arthritis. Peer learners share their approaches to diagnosing and treating the patient, and the group moderator critiques the answers, highlighting the importance of addressing the underlying pathology and the limitations of current medical practices.
Key Words
1. Medical education
2. Over-testing
3. Overtreatment
4. Hypertension
5. Diabetes
6. Rheumatoid arthritis
7. Medical cognition
8. Evidence-based medicine
9. Artificial intelligence
UDLCO glossary : http://userdrivenhealthcare. blogspot.com/2023/11/glossary- of-user-driven-healthcare. html?m=1
[06/01, 19:44] group moderator : A 53 year old female, with medically controlled diabetes, under metformin 500 bd, is suffering from morbid hypertension. The average diurnal PBP being 180/100
The patient is on telmisartan/metoprolol 40/50 in combination.
The patient is a patient of clinically diagnosed RA under methotrexate 7.5 bi weekly.
Renal profile is normal with no dyselectrolemia, creatinine 0.8
Hb 10
TLC WNL
Thyroid profile WNL.
Lipid profile WNL
How to approach the case to diagnose the underlying pathology and how to escalate the anti hypertensives?
Please opine and oblige...
[07/01, 03:04] peer learner 1: How I might have approached the case-
Firstly if her bp still averages 180/100 after telmi/metopr, then I wld firstly admit her & start on injectable diuretics (Lasix 10mg TDS later tapering to BD & so on) in conjunction with Nicardia 20 mg SOS if BP still persists above 140/90 mm Hg after her lasix & Telmi/Metoprolol..
In RA, body is under oxidative stress too which probably also plays a role in HTN, so I'll provide her with some antioxidant combination & MVI too..
Then if her bp starts returning to baseline I'll discharge her by switching her bp med to a readily available standard combination of Chlorthalidone-Telma-Am tabletπ€ also since due to oxidative stress & inflammation assoc with RA & Morbid Htn on top of that, she is at severe risk of any Cerebrovascular or Cardiovascular adversity, I'll advice her to switch from metformin to glifozins which are known to be protective in cardiac related scenarios..."
Clinical problem question scenario over.
Question to:
Medical cognition (integrating medical education and practice) learners and enthusiasts:
Can you identify the medical cognition drivers to over-testing and overtreatment captured in this real (but deidentified) peer to peer online learning scenario.
Can you as a first step begin by pointing out the non evidence based interpretations of medical data that arises out of too much focus on hypothetical pathophysiologies and too less on RCT data?
On Wed, 8 Jan 2025, 09:18 ap wrote:
Happy New Year! This is a great concept! Might you frame it like NEJM and personalize it for co-productive community medicine? This way you could broaden your impact as you are making a puzzle (medical mystery) to solve by all. This appeals to all and can bring in cultural relevance, local barriers etc…
Date: Wed, 8 Jan 2025, 09:52 rb
Reminded of the prolific framings of such similars I used to engage in around 2000 at one column called "images in clinical medicine"!
Unfortunately while they have pubmed traces the full text may have disappeared from everywhere else: https://pubmed.ncbi.nlm. nih.gov/15055875/
I guess I moved to framing them rather loosely in blogspot as there's no rigorous peer review to get there but it may still thrive asynchronously through human life long post publication peer review if not AI bot user driven processing!
On Sun, 12 Jan 2025, 17:24 rk> wrote:
This is very fascinating. It will take some time but I'm trying to model all these decisions in a causal reasoning graph. Lets see if that representation is able to quickly point out where the mistakes were.Quick question -
- For differential diagnosis, I'm familiar with STW (https://www.icmr.gov.in/
icmrobject/custom_data/pdf/ downloadable-books/STW_Vol_3_ 2022.pdf) that you had once shared, and also stumbled upon a pdf of this book which seems pretty detailed (https://www.amazon.in/ Differential-Diagnosis- Internal-Medicine-Symptom/dp/ 313142141X). - Are there any resources for diff diagnosis that you would recommend relevant to this case? I really like the detail and decision tree format that NCCN has e.g. see page 11 (https://www.nccn.org/
professionals/physician_gls/ pdf/all_blocks.pdf).
On Tue, 14 Jan 2025, 19:43 rb > wrote:
My answer is also a critique of the answer given by peer learner 1.The question by the original poster OP was:How to approach the case to diagnose the underlying pathology and how to escalate the anti hypertensives?Peer learner 1 in his answer chooses to ignore the first half of the question and simply jumps to fix the hypertension!One answer to the first component of the question, "How to approach the case to diagnose the underlying pathology"is: It's easy if one can spot the phenotype!Here's how the phenotype of a metabolic syn patient may look like (as in the opening clinical image in the link): https://medicinedepartment.blogspot. com/2024/10/clinical- complexity-project-individual. html?m=1 Essentially it's about accumulating a lot of adipocytes around the trunk!There are some western repositories offering a loose eye ball estimated visual representation of body fat such as here:We have much more visual images in our departmental patient centered metabolic syn data base that needs an AI to cluster them in the above format hopefully in the near future and we are even currently wondering how to register all our images in Wikimedia commons (if anyone could help to work out the logistics)!Coming back to the pathophysiology:These adipocytes are very metabolically active and a key driver to the underlying pathophysiology of hypertension through endothelial inflammation and fibrosis causing vessel stiffness.The second component of the answer is the trickiest and also would be the most impactful area we can work on with the help of AI driven PICO format evidence generators for each therapeutic choice!But again more importantly one is likely to realise that there's not much evidence for any of the BP lowering pharmacological interventions in improving long term organ failure outcomes and it's logical that eliminating the risk factors for development of trunkal obesity is more likely to be a scientific cure than simply producing a cosmetic effect on the BP using vasodilators or diuretics!Thematic Analysis_Codes_1. Medical education2. Case scenario discussion3. Diagnostic approach4. Treatment options5. Critique of medical practices6. Evidence-based medicine7. Artificial intelligence_Themes_
1. _Medical Education and Cognition_: The conversation highlights the importance of medical education and cognition in shaping medical practices.
2. _Diagnostic Approach_: The discussants share their approaches to diagnosing the patient, emphasizing the need to address the underlying pathology.
3. _Treatment Options and Limitations_: The conversation critiques the treatment options presented, highlighting the limitations of current medical practices and the need for evidence-based medicine.
4. _Role of Artificial Intelligence_: The discussants mention the potential role of artificial intelligence in improving medical practices and generating evidence-based guidelines.Learning Points
1. _Importance of Addressing Underlying Pathology_: Medical practitioners should focus on addressing the underlying pathology rather than just treating symptoms.
2. _Limitations of Current Medical Practices_: Current medical practices may not always be evidence-based, and practitioners should be aware of these limitations.
3. _Need for Evidence-Based Medicine_: Evidence-based medicine is crucial in ensuring that medical practices are effective and efficient.
4. _Potential Role of Artificial Intelligence_: Artificial intelligence can play a significant role in improving medical practices and generating evidence-based guidelines.
Image from: https://medicinedepartment.blogspot.com/2024/01/medical-cognition-cpd-jan-25-2024theme.html?m=1